PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review

Rajendran, Peramaiyan; Sekar, Ramya; Dhayasankar, Prabhu Shankar; Ali, Enas M; Abdelsalam, Salaheldin Abdelraouf; Balaraman, Sabarinath; Chellappan, Biju Vadakkemukadiyil; Metwally, Ashraf M.; Abdallah, Basem M

doi:10.7150/ijms.94566

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Int J Med Sci 2024; 21(6):1165-1175. doi:10.7150/ijms.94566 This issue Cite

Review

PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review

Peramaiyan Rajendran^1,2✉*, Ramya Sekar^3,2✉*, Prabhu Shankar Dhayasankar⁴, Enas M Ali^1,5, Salaheldin Abdelraouf Abdelsalam^1,6, Sabarinath Balaraman³, Biju Vadakkemukadiyil Chellappan¹, Ashraf M. Metwally^1,7, Basem M Abdallah¹

1. Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
2. Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, Tamil Nadu, India.
3. Department of Oral Pathology & Oral Microbiology, Meenakshi Ammal Dental College and Hospital, MAHER, Alapakkam Main Road, Maduravoyal, Chennai-600095, India.
4. Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College and Hospital, MAHER, Alapakkam Main Road, Maduravoyal, Chennai-600095, India.
5. Department of Botany and Microbiology, Faculty of Science, Cairo University, Cairo, 12613, Egypt.
6. Department of Zoology, Faculty of Science, Assiut University, Assiut, 71515, Egypt.
7. Botany and Microbiology Department, Faculty of Science, Assiut University, Assiut 71516, Egypt.
* Equal First Authorship.

Citation:

Rajendran P, Sekar R, Dhayasankar PS, Ali EM, Abdelsalam SA, Balaraman S, Chellappan BV, Metwally AM, Abdallah BM. PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review. Int J Med Sci 2024; 21(6):1165-1175. doi:10.7150/ijms.94566. https://www.medsci.org/v21p1165.htm

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Abstract

Oral cancer is the most heterogeneous cancer at clinical and histological levels. PI3K/AKT/mTOR pathway was identified as one of the most commonly modulated signals in oral cancer, which regulates major cellular and metabolic activity of the cell. Thus, various proteins of PI3K/AKT/mTOR pathway were used as therapeutic targets for oral cancer, to design more specific drugs with less off-target toxicity. This review sheds light on the regulation of PI3K/AKT/mTOR, and its role in controlling autophagy and associated apoptosis during the progression and metastasis of oral squamous type of malignancy (OSCC). In addition, we reviewed in detail the upstream activators and the downstream effectors of PI3K/AKT/mTOR signaling as potential therapeutic targets for oral cancer treatment.

Keywords: oral cancer, PI3K/AKT, autophagy, metastasis

Citation styles

APA

Rajendran, P., Sekar, R., Dhayasankar, P.S., Ali, E.M., Abdelsalam, S.A., Balaraman, S., Chellappan, B.V., Metwally, A.M., Abdallah, B.M. (2024). PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review. International Journal of Medical Sciences, 21(6), 1165-1175. https://doi.org/10.7150/ijms.94566.

ACS

Rajendran, P.; Sekar, R.; Dhayasankar, P.S.; Ali, E.M.; Abdelsalam, S.A.; Balaraman, S.; Chellappan, B.V.; Metwally, A.M.; Abdallah, B.M. PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review. Int. J. Med. Sci. 2024, 21 (6), 1165-1175. DOI: 10.7150/ijms.94566.

NLM

CSE

Rajendran P, Sekar R, Dhayasankar PS, Ali EM, Abdelsalam SA, Balaraman S, Chellappan BV, Metwally AM, Abdallah BM. 2024. PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review. Int J Med Sci. 21(6):1165-1175.

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